Recent advances in nanotechnological strategies for the therapy of various neurodegenerative disordersName : Dr. Ghulam Md Ashraf
Affliation : Assistant Professor
University : King Abdulaziz University
Country : Saudi Arabia
Nanotechnology exploits materials and devices with a functional organization that has been engineered at the nanometre scale. Nanotechnology based approaches (NBA) favoured transcytosis-mediated delivery of nanoparticles to the brain by crossing the BBB. The application of nanotechnology in neuroscience involves specific interactions with neurons and glial cells. This property is used for delivering drugs and other small molecules (such as genes, oligonucleotides and contrasting agents) across the blood brain barrier (BBB), an important requirement for delivering the drug successfully to the brain. It is expected that the development of novel NBA will result in important insights on the brain mechanisms, and eventually provide better medical care to patients suffering from neurological disorders. The last 5 years have witnessed the successful applications of NBA to treat neurological disorders. This brief review introduces the emerging work in this area and summarizes the successful NBA used in the most recent past for treating Alzheimer’s disease, Parkinson’s disease, amyotrophic lateral sclerosis, meningitis and glioblastoma.
Dr. Ghulam Md Ashraf is an Assistant Professor at King Fahd Medical Research Center at King Abdulaziz University, Jeddah, Saudi Arabia. He received his B.Sc (2004), M.Sc. (2006) and PhD (2010) degree from Department of Biochemistry, Faculty of Life Sciences, Aligarh Muslim University, Uttar Pradesh, India. The current focus of his research is neuroproteomics, with the quest to investigate the application of proteomics and nanotechnological tools in understanding the mechanism underlying neurodegeneration in neurodegenerative diseases, and finding drugable targets to counteract neurodegeneration. Currently, Dr Ashraf is carrying out an ambitious project which involves an extensive analyses of the cerebrospinal fluid collected from neurodegenerative patients who undergo neurosurgery. The aim of this study to investigate a definitive expression pattern of all the CSF markers of neurodegeneration, and thus establish a potential early stage diagnosis of neurodegenerative disorders.