Evaluation of brain atrophy by MRI and regional tau deposits by 18F-THK5351 PET in Alzheimer’s diseaseName : Dr. Hiroshi Matsuda
Affliation : Professor
University : National Center Of Neurology And Psychiatry
Country : Japan
Background: The recent advent of tau-specific positron emission tomography (PET) has enabled in vivo assessment of tau pathology in Alzheimer’s disease (AD). However, because PET scanners have limited spatial resolution, the measured signals of small brain structures or atrophied areas are underestimated by partial volume effects. The aim of this study was to determine whether partial volume correction (PVC) improves the precision
Materials and Methods: We investigated tau deposits in 18 patients with amyloid-positive early AD and in 36 amyloid-negative healthy controls using 18F-THK5351 PET. For PVC, we applied the SPM toolbox PETPVE12. The PET images were then spatially normalized and subjected to voxel-based group analysis using SPM12 for comparison between the early AD patients and healthy controls.
Conclusion: PVC did not significantly affect 18F-THK5351 PET measures of tau deposits. This discrepancy between tau deposits and atrophy suggests that tau load precedes atrophy.
Biography: Graduated with a degree in Medicine at Kanazawa University School of Medicine in 1979. Then finished the doctor’s course at Graduate School of Kanazawa University School of Medicine in 1983. He specializes in radiology especially in nuclear medicine. He was a Rotary Foundation scholar from 1984 to 1985 at Montreal