Olive biophenols: Beyond the antioxidant in Alzheimer’s diseaseName : Dr. Syed Haris Omar
Affliation : Lecturer
University : Endeavour College Of Natural Health
Country : Australia
Alzheimer's disease (AD) is the most common neurodegenerative disease, characterized by notable memory loss, cognitive impairment, and neuron death in the brain of aged population. The pathophysiology includes the oxidative stress, metal deposition, formation of aggregates of amyloid and tau, and imbalance in cholinergic system. Currently, there is no effective pharmacological treatment, however, FDA approved drugs for AD offer symptomatic relief without preventing the progression of the disease and having limited efficacy. Increasing evidence suggests that the biophenols plays a key role in improving cognitive functions and preventing/delaying the onset of certain neurodegenerative diseases including AD. In the recent study, the antioxidant activity of olive biophenols in the cell free system were shown highest by quercetin (EC50: 93.97 μM) and verbascoside (EC50: 0.66 mM) against the SOR and H2O2 toxicity. In addition, the olive extracts (OLE and HTETM) were highest SOR (EC50: 1.89 μg/mL) and H2O2 (EC50: 115.8 μg/mL) scavengers. The olive biophenols, caffeic acid (77% and 64%), verbascoside (71% and 72%) and olive extract (HTETM) (98% and 92%) were showed the highest neuroprotection against H2O2-induced and Cu-induced toxicities in neuroblastoma (SH-SY5Y) cells. The results suggest that olive biophenols potentially serve as agents for the prevention of neurodegenerative diseases such as AD, and other neurodegenerative ailments that are caused by oxidative stress.
Keywords: Alzheimer’s disease, olive biophenols, caffeic acid, verbascoside, SH-SY5Ycells.
Dr. Syed Haris Omar working as a lecturer in Bioscience at Endeavour College of Natural Health, Melbourne, Australia, and having >8 years of lectureship experiences. He received Bachelor and Master of Pharmacy degree, and awarded his PhD in Pharmacology from the School of Biomedical Sciences, Charles Sturt University, Australia in 2016. His research work was focused on Alzheimer’s disease prevention and treatment by using naturally derived olive biophenols. Dr. Haris use transgenic mice models of Alzheimer’s disease to contribute in the better understanding of the plant biophenols role as an alternative approach against the amyloid-beta toxicity in Alzheimer’s disease. His research interest lies in the area of pharmacology, neuropharmacology, and natural products against the neurodegenerative diseases. He is a board member in The Human Research Ethics Committee (HREC) at Endeavour College of Natural Health. He has published several peer-reviewed article including research, reviews, book chapters and conference papers, and serving as Editorial board member and reviewer in the journals of repute. Currently, he is serving as a member in The Australian Society of Clinical and Experimental Pharmacologists and Toxicologist (ASCEPT), Australian Society for Biochemistry and Molecular Biology (ASBMB), American Chemical Society (ACS), American Association for the Advancement of Science (AAAS), and American Oil Chemist Society (AOCS). In addition, he is Vice Chair in the Local Health Advisory Committee, NSW Health, board member in the Australia Day Community Committee, and in the Riverina Family Law Pathway Network Steering Committee.