Syed Haris Omar and his team have discussed on Impacts of Anti-Alzheimer Drug Discovery in the article entitled “Biophenols: Impacts and Prospects in Anti-Alzheimer Drug Discovery”. This article was published in Journal “Alzheimer’s” under the section “Anti-Alzheimer Drug Discovery” published 9 June 2017.
Alzheimer disease (AD) is a multifactorial neurodegenerative disorder and the most common form of dementia characterized by age-dependent memory loss, ultimately leading to a steady decline of cognitive function. Increasing evidences supporting the dietary role in AD, including the intake of naturally occurring biophenols from the plants having pleiotropic bioactivity, which significantly decrease the Aβ burden and improve the cognitive impairment conditions through their potent antioxidant and peptide modification mechanisms. In this chapter, the in vitro and in vivo protective effects of different sources of biophenols and their antiamyloid, anti-tau, anticholinesterase, and cognitive enhancement activities are described, which have provided an evident background toward the future clinical research against AD.
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